Traumatic and Ischemic Injury Methods and Protocols 2018
Traumatic and ischemic injuries are some of the most devastating diseases and are responsible for high mortality and morbidity worldwide. Over the past decades, significant research has been conducted in this area, aimed at reducing or preventing complications after a traumatic or ischemic injury.This Traumatic and Ischemic Injury Methods and Protocols 2018 volume is part of the Methods in Molecular Biology series and I hope will allow beginners with limited experience to initiate new research projects and established investigators to identify other comparable approaches and strategies.
The first few chapters in Traumatic and Ischemic Injury Methods and Protocols 2018 are mainly focused on some of the selected animal models and procedures commonly used in traumatic injury research followed by a chapter on hemorrhagic stroke. After that, a series of chapters on various ischemic injuries followed by some of the chapters specifically addressing sepsis models have been included.
The last few chapters in Traumatic and Ischemic Injury Methods and Protocols 2018 are dedicated to selected in vitro models from the field.The use of a suitable animal model that exhibits many of the pathophysiological features
of any disease is important for the identification of therapeutic targets and future drug development to alleviate its symptoms. A wide variety of small and large animal models are currently available for researchers working in the field of traumatic and ischemic injuries.
The major advantage of using animals in research in these fields is the ability to obtain scientific information under well-defined conditions that closely mimic specific clinical scenarios. So, in the field of traumatic and ischemic injuries, it is important to continue animal studies and to develop new animal models and protocols that better reflect the clinical setting to gain further insight into the underlying cellular, biochemical, and physiological
The general trend in the field is to use laboratory rodents to answer fundamental questions regarding cellular and molecular mechanisms while physiological processes are more commonly investigated in large animals due to the similarity to humans. The main focus of this volume was to compile the procedures for the development
and application of several of such research models and techniques with the help from experts in their respective fields.